Neodnokratno perenesennaya tyazhelaya insulinovaya gipoglikemiya u krys privodila k uvelicheniyu aktivnosti aminotransferaz, glutaminazy i glutamatdegidrogenazy v pecheni, uvelicheniyu aktivnosti proteaz v tkanyakh, uvelicheniyu urovnya svobodnykh zhirnykh kislot, mocheviny i mochevoi kisloty v syvorotke krovi. Obnaruzhennye izmeneniya svidetel'stvovali ob aktivatsii glyukoneogeneza u zhivotnykh, podvergnutykh giperinsulinizatsii. V golovnom mozge nablyudali umen'shenie intensivnosti glikoliza i glikogenoliza, aktivnosti NADF-zavisimykh degidrogenaz i sushchestvennye izmeneniya aktivnosti fermentov nukleotidnogo obmena i obmena mediatornykh aminokislot. Vyyavlennye izmeneniya byli preimushchestvenno svyazany s gipoglikemiei i aktivatsiei kontrinsulyarnogo apparata i mogli imet' sushchestvennoe znachenie v patogeneze postgipoglikemicheskoi entsefalopatii.

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