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Biophysics
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Vol. 50, No. 5, September-October 2005, pp. 786-790
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A Possible Molecular Mechanism of the Narcotic Action of Noble Gases
V. V. Dovgusha1, M. V. Fok2, and G. A. Zaritskaya2
1State Unitary Enterprise Research Institute of Industrial and Marine Medicine, Ministry of Health of the Russian Federation, pr. Yu. Gagarina 67, St. Petersburg, 196143 Russia
2Lebedev Physical Institute, Russian Academy of Sciences, Leninskii pr. 53, Moscow, 119991 Russia
Received June 7, 2004
in final form November 26, 2004
Key words: narcotic action of noble gases, molecular mechanism, orientation of water molecules, electrostatic interaction.A molecular mechanism of the narcotic action of noble gases is suggested. It is based on the fact that noble gas atoms disturb the orientation of water molecules absorbed on the surface of an axon membrane. The resulting change in the transmembrane potential hampers the conduction of a nerve impulse along the axon and its transduction across synapses to another nerve cell, since the nerve impulse consists in a local change in the direction of the electric field in the membrane. References - V. V. Dovgusha and A. Yu. Sledkov, Narcosis: A Concept of Electromagnetic (Frequency-Field) Mechanisms of Occurrence (GUP NII Promysh. Morskoi Meditsiny, St. Petersburg, 2003) [in Russian].
- M. V. Fok, A. R. Zaritskii, G. A. Zaritskaya, and E. V. Perevedentseva, Self-Regulation Nonspecific Permeability of Erythrocyte Membrane (Nauka, Moscow, 1999) [in Russian].
- M. V. Fok, Some Questions of Biochemical Physics Important for Physicians (Nauka, Moscow, 2003) [in Russian].
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PII: S0006350905050192
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