Low-Density Lipoproteins with Different Aggregation Ability
G. E. Dobretsov1, S. K. Gularyan1, O. M. Panasenko1, A. N. Orekhov2, and S. I. Isakova1
1Research Institute of Physicochemical Medicine, Ministry of Public Health, Moscow, 119992 Russia
2Research Institute of Atherosclerosis, Russian Academy of Natural Sciences, Moscow, 121609 Russia
Received April 16, 2004
in final form September 14, 2004
Key words: low-density lipoproteins, lipoprotein aggregation, atherogenesis.
The preparations of low-density lipoproteins isolated from the blood of healthy donors were found to contain particles of lipoproteins showing different aggregation ability: some particles undergo aggregation much faster than others upon stirring of a lipoprotein solution. After stirring, lipoprotein particles can be separated by ultracentrifugation into two fractionslarge aggregates and small particleswithout intermediate forms. It is known that the presence of aggregated low-density lipoproteins can accelerate considerably the accumulation of lipids in cells; therefore, one can suppose the particles with high aggregation propensity to be more atherogenic.
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